There are 47 achievements worth a total of 1000 points
Complete Act 1 on any difficulty level
Complete Act 2 on any difficulty level
Complete Act 3 on any difficulty level
Complete all levels on Normal
Complete all levels on Hard
Defeat 100 enemies
Defeat 500 enemies
Web of Challenges - Obtain all Gold Medals for a Chapter
Web of Challenges - Obtain all Gold Medals for an Act
Web of Challenges - Obtain all Gold Medals
Obtain 1/4 of the Golden Spiders
Obtain 1/2 of the Golden Spiders
Obtain all Golden Spiders
Buy all Combat Upgrades
Buy all Character Upgrades
Obtain all Alternate Suits
Execute a 50-hit combo
Execute a 100-hit combo
Execute a 200-hit combo
Collect 500 Orb Fragments
Collect 1000 Orb Fragments
Collect 2000 Orb Fragments
Complete Session 3 or later without dying
Perform 3 of each type of Grab Attacks on enemies
Perform 3 of each Air Attack on enemies
Damage enemies with Roundhouse Spin and Web Hammer 10 times each
Gained access to the Restricted Archives Computer
Gained access to the Future Restricted Area
Defeated the CEO on any difficulty level
Defeated Atrocity on any difficulty level
Collected all three Atomic Fuses
Floor 66 Reached
Stopped the future from becoming a radioactive wasteland
Analyzed all Data Modules
Saved Mary Jane
Teleported back to Alchemax with the Key
Retrieved all three DNA Samples from the knocked-out Atrocity
Brought the Incinerator to Maximum Power
Erased the Prototype Combat Robot from existence
Defeated Anti-Venom on any difficulty level
Spider-Man was down and out
Foreseen the death of Spider-Man
Defeated Black Cat on any difficulty level
Obtained all Newspapers
Avoided 100 attacks with Accelerated Decoy
Evaded 100 attacks with Hyper-Sense
Completed a Freefall section by boosting the entire time